2. Early Diagnosis of Rheumatoid Arthritis and Prediction of Progression of Joint Destruction
نویسندگان
چکیده
منابع مشابه
Rheumatoid Arthritis: Early diagnosis and treatment outcomes
Rheumatoid arthritis (RA) is an inflammatory progressive disease which in the absence of appropriate treatment can lead to joint destruction and disability. Prognosis of RA may be predicted based on the presence of some clinical and laboratory evidences.New criteria for classification of RA provides opportunity for earlier treatment. Initiation of treatment particularly by combination of DMARDs...
متن کاملrheumatoid arthritis: early diagnosis and treatment outcomes
rheumatoid arthritis (ra) is an inflammatory progressive disease which in the absence of appropriate treatment can lead to joint destruction and disability. prognosis of ra may be predicted based on the presence of some clinical and laboratory evidences.new criteria for classification of ra provides opportunity for earlier treatment. initiation of treatment particularly by combination of dmards...
متن کاملGenetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study.
BACKGROUND Interleukin (IL)-15 levels are increased in serum, synovium and bone marrow of patients with rheumatoid arthritis (RA). IL-15 influences both the innate and the adaptive immune response; its major role is activation and proliferation of T cells. There are also emerging data that IL-15 affects osteoclastogenesis. The authors investigated the association of genetic variants in IL15 wit...
متن کاملA genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis
INTRODUCTION Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL (Receptor Activator for Nuclear Factor κ B Ligand) to RANK results in the activation of TRAF6 (tumor necrosis factor (TNF) receptor associated factor-6), and osteoclast formation ultim...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2008
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.97.103b